Sunday, May, 18, 2008

INFORMATICS & DECISION SUPPORT TRACK

Monday, May 19, 2008

10:10 Chairperson’s Remarks
Randy Clark, Vice President, Marketing, Symyx Technologies, Inc.

10:15 Having Your Cake and Eating It Too: How Vendor/Customer Collaborations Produce a Better Electronic Laboratory Notebook
Stan Piper, B.Sc., M.B.A., Senior Scientist, Analytical R&D, Pfizer Global Research & Development
Increasing external pressures are forcing organizations to continuously improve efficiencies. As the amount of data within those organizations continues to increase, scientists need new ways to acquire, compile, search, visualize and report that data. The use of an Electronic Laboratory Notebook (eLN) enable scientists to meet this need. As the eLN market matures, organizations have more choices surrounding their eLN applications. Most customers have similar drivers behind their eLN implementations. These drivers likely go beyond simply replacing paper based system, and organizations now look to their eLN systems to serve as a key piece of a total lab informatics solution. Some of the more simple drivers include fewer transcriptions and manual calculations, improved compliance, improved IP protection, and enabling collaboration. The more complex drivers require the eLN to: serve as an access to mine empirical data, aid in design and planning of experiments, reduce cycle times through automation, link to other enterprise systems such as LIMS and CDS. So with these drivers in mind, an organization must decide which eLN product to implement, and then once chosen must determine how to configure the application to fully realize all of these success criteria. This presentation will discuss the current state of the electronic lab, the issues surrounding software in the lab environment and the importance of partnering with software vendors to develop features and functions in an eLN.

10:45 Incorporating Symyx Notebook into a System for Recording GMP Manufacture of Clinical Trials API with Improved Quality Management
John Leonard, Ph.D., Principal Scientist and Process Chemistry Research Manager, AstraZeneca
We have been piloting the use of Symyx Notebook for the preparation of Batch Instructions and Batch Records for the manufacture of clinical trials API. Process chemists and pilot plant chemists have worked closely with QA representatives to develop a new electronic system for transferring processes from the research labs into GMP manufacturing facilities. The new Symyx-based system provides a more accurate method of process transfer together with an efficient and transparent electronic batch recording procedure. It also incorporates a completely revised approach to batch documentation and quality management, which is based on Symyx Vault and has led to a significant reduction in bureaucracy.

11:15 The ELN as a System Integration Platform for the Lab
Ulf Fuchslueger, Ph.D., Chief Operating Officer, Vialis GmbH
The efficiency of data ex- and interchange is one of the key drivers for productivity of modern laboratories in research and development. In recent years many organisations have established ELN’s to support their research and development labs but only in rare cases the integration aspects with other applications and departments – especially outside the lab environment - have been considered. This talk addresses some typical integration aspects encountered when implementing an ELN and highlights conceptional approaches to establish an ELN as the integration platform for the lab.

2:25 Chairperson’s Remarks
Randy Clark, Vice President, Marketing, Symyx Technologies, Inc.

2:30 The Quest for an ELN - The Need for a Reaction Management System
Danny Verbinnen, Pharma R&D IM - Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development

3:00 Integration of Electronic Notebook Software into the Workflow of an Academic Research Group
Ulrich Jordis, Ph.D., Professor, Vienna University of Technology, Institute of Applied Synthetic Chemistry
In our attempts to stay on top of the developments of integrating software and databases into the daily workflow of a synthetic/medicinal chemist, we have been using electronic notebook software (including ELAN, MDL Notebook and ChembridgeSoft e-notebook). This talk will cover issues of usability and a wish-list for further versions of this software that most likely will merge with other Symyx lab journal solutions.

4:00 Speed-Based Development
Kurt Swogger, Senior Consultant, Cincinnati Consulting Consortium, Retired Vice President, R&D, Dow Chemical Company

4:30 Executive Roundtable - Taking a New Approach to R&D – Innovation, Technology & Automation
Innovation is one of the most discussed and elusive topics in business. Hear from successful, life-long practitioners, in their own words, discuss what works, what doesn’t and what they have learned over the business cycles. The backdrop of Symyx Symposium will provide hands-on context to what 21st century scientific R&D faces as industries globalize and restructure. This is an opportunity for thought-leaders and change-agents to share experiences and practical advice across a range of topics.

Executive Panelists:
Keith Grime, Ph.D., President, JKG Consulting, Adjunct Professor, Department of Chemical & Biological Engineering, Northwestern University
Wim Roels, M.Sc., Vice President, Innovation & Technology, R&D, Borealis AG
Kurt Swogger, Senior Consultant, Cincinnati Consulting Consortium, Retired Vice President R&D, Dow Chemical Company
Klaus Kuhlein, Ph.D., Consultant, Former Head of Central Research, Hoechst AG
Keith M. DeVries, Ph.D., Director, Chemical Product R&D, Eli Lilly and Company
Stephan Taylor, Ph.D., Director, Project & Process Optimization Systems, Process R&D, Bristol-Myers Squibb Pharmaceuticals Research Institute

5:30 End of Day

Tuesday, May 20, 2008

10:00 Chairperson’s Remarks
Randy Clark, Vice President, Marketing, Symyx Technologies, Inc.

10:05 Integrating Symyx Stock Management Solution into IPSEN Information System
Olivier Lamarche, Ph.D., International Project Manager, R&D Informatics, Ipsen
With the prime intention of being compliant with regulatory constraints, IPSEN has chosen Symyx Logistics to manage the life cycle of commercially available and internal chemical products. The solution, implemented and customized by a successful collaboration between Symyx professional services and IPSEN team, managed H&S information and has been swiftly integrated into IPSEN information system. Users across different departments have quickly adopted the intuitive multi-function interface accessing related corporate and commercial databases.

10:35 Ciba’s Integrated Platform to Support Global Innovation Process
Klaus Stumpf, Ph.D., Business Liaison I&PLM, Global Information Services, Ciba Inc.
Within Ciba’s Research and Development (R&D), a new Global Innovation Process (GIP) has been implemented as part of the Product Life Cycle. Now the whole landscape of applications for the R&D community - comprising scientific data management systems, content and document management systems, knowledge management, and laboratory data management - has to be integrated. The basic concept to stick all parts together is the Global Substance Identifier (GSI). These Global Substance Identifiers and their common data for R&D will be managed within PHOENIX, Ciba’s new R&D Information System. This system is based on Symyx ISENTRIS. The open design of ISENTRIS makes it easy to replace the application-oriented view of users with a business process-oriented and content-oriented view. The user is able to focus on his/her business needs and is no longer bothered with IT questions.

11:05 Development of Symyx Isentris 3.0 and Integration with a Registration
Tool: From Record Filing to Reporting in a While
Carlo Riva, Ph.D., Head of Chemical Synthesis, Medicinal Chemistry Department, Pharmaceutical Research and Development Division, Recordati Industria Chimica e Farmaceutica S.p.A.
Recordati Drug Discovery further developed its own integrated discovery informatics system, a relatively simple system, which utilizes some default Symyx programs and databases, joined with some custom applications, developed in collaboration with Symyx. MDL Isentris 2.0 was migrated to Symyx Isentris 3.0, which in turn was customized and integrated with the pre-existing custom application RecBio (now re-written in a dotnet architecture). RecBio allows a very effective analytical, biological or any protocol and related document management, strictly integrated with Symyx Assay Explorer. Isentris based Custom Registration Tools were developed to complete the entire job and allowing Recordati Drug Discovery to effectively abandon Symyx Isis Host and Isis Desktop in the overall process of using the proprietary databases. The overall system offers the capability of more complex IT systems for data management. Joined to the benefits displayed by the Discovery Gate package, it affords real benefits in term of data searching, displaying, reporting and, finally, research productivity.

11:35 DiscoveryGate and Reference Database Web Services
Russ Hillard, Ph.D., Senior Product Manager, Symyx Software
Recent enhancements to the DiscoveryGate online content platform will be described. Use cases will be presented that illustrate how DiscoveryGate provides direct answers to research questions including: preparation or procurement of known compounds, reported properties of known compounds, and synthetic methods suitable for making novel compounds. Web service access to the Symyx Available Chemicals Directory database will be described. Progress toward extended web service access to all Symyx Reference Databases will be demonstrated and a roadmap for new online content services will be presented.

1:10 Chairperson’s Remarks
Randy Clark, Vice President, Marketing, Symyx Technologies, Inc.

1:15 Symyx Software Roadmap
Trevor W. Heritage, Ph.D., Senior Vice President, Science, Symyx Software
Trevor’s presentation will discuss the exciting potential customers are already seeing in Symyx Software’s product road map-their ability to start in Symyx Notebook and never leave and their ability to start in Symyx Isentris and go anywhere. Trevor will outline development plans for 2008 and 2009, specifically addressing Symyx Notebook and Symyx Isentris, as well as Symyx Draw, ISIS, DiscoveryGate, Automation Studio and Analysis Studio. He will also highlight specific areas within discovery and development including: biology, catalysis, medicinal chemistry, process, formulations and analytical.

2:15 Experiences from the Global Rollout of a Customized Logistics Application at Boehringer Ingelheim
Georg G. Otto, Ph.D., System Analyst, Deptartment of Information Technology, Boehringer Ingelheim Pharma GmbH & Co KG
An efficient workflow to search, retrieve and maintain chemical reagents is a key asset for every Pharma Company. To improve efficiency, reduce costs and satisfy upcoming regulatory needs Boehringer was looking for a next generation Logistics System that would replace the legacy CIMS applications and cope with changes of interfacing hardware.
This presentation will summarize how Boehringer Ingelheim has successfully implemented Symyx Logistics in various sites globally. Site specific customizations at Biberach, Germany and Ridgefield, USA, as well as data migration, technical setup of the Isentris Architecture, performance aspects and end user training are covered. In particular the challenges in a global pharma environment, like interface to various purchasing systems, custom prices and automated vertical storage robotics and their implementation will be explored.

2:45 Implementation of Assay Explorer into the Drug Discovery ADME Workflow
Thomas Arnhold, Ph.D., Principal Scientist, Department of Drug Discovery Support, Boehringer Ingelheim GmbH & Co. KG
Microsoft Excel is the data analysis tool of choice for many labs, since it allows flexible data analysis. However, our raw data analysis had to be adjusted in order to
a) meet the increasing demand for ADME profiling of research compounds and
b) be able to realize an entire workflow concept from the assay request to the delivery of calculated results.
The implementation of Assay Explorer as one unit of the whole workflow concept for routine in vitro ADME assays will be demonstrated.

3:45 Manchester Organics Catalogue Editor Showcase
James Jack, Ph.D., BSc, M.R.S.C., Senior Consultant, Symyx Technologies, Inc.
Written using Symyx Isentris and .Net, the Manchester Organics Catalogue Editor uses a specially extended version of the Isentris Controls to allow in place inserts and updates to a database without the need for a specialized registration service (it performs a simple duplicates check, but does not apply business rules / salt stripping).
The Catalogue Editor is much more that its name suggests: it allows Manchester Organics to not only store, search and report / print their 3000 compounds and growing catalogue (including printing of labels), but much more than this, it tracks pricing and quote information alongside competitors pricing, has some integration with a SAGE accounting package and tracks batches of compounds, their locations, the dates they were sold, etc. It also contains an MSDS authoring tool to allow the creation of MSDS sheets for the compounds on sale in the catalogue. This presentation will discuss how the catalogue editor was developed, its features and uses, and future opportunities.

4:15 Notebook Integration – What’s In It For Me?
Stephen Taylor, Ph.D., Director, Project & Process Optimization Systems, Process R&D, Bristol-Myers Squibb Pharmaceutical Research Institute
An overview of the opportunities for ELN integration leveraging notebook content to support connectivity to existing systems and data transfer back to the ELN. Such integration can improve the users’ productivity, eliminate duplication of effort, eliminate errors, and provide context to data in disparate systems. Integration should go beyond supporting existing workflows and enable scientists to gain insights into their data. The factors that should be considered when integrating will be reviewed, including when to integrate and when not to integrate.

4:45 Electronic Lab Notebooks, a Turning Table for Chemical/Pharmaceutical Development Activities at Johnson and Johnson
Marijke Massy, MS, Program Manager, Janssen Pharmacuetica
In this presentation you will learn how the Electronic Lab Notebook system became a platform supporting development activities within the global Chemical Pharmaceutical Development Department of Johnson and Johnson, from early development up to commercial support. You will also hear about the results of a pilot with the Symyx Lab Execution & Experiment Analysis software, which can generate additional benefits for the development organization.

5:15 Development of NNCD SAR and Browse with Isentris 3.0: Replacing ISIS Based Applications
John Gregersen, Novo Nordisk A/S, and Knut Ostrom, Symyx Technologies, Inc.
Old trusted ISIS base applications tend to linger for various good reasons. However, new generations of chemists, emerging technologies, new opportunities for client and server side integration, and new business needs all calls for exploitation of the opportunities provided by Isentris 3.0 software. Informatics systems, handling molecules, have for a long period been favouring small molecule chemists, leaving protein based research with separate specialised tools that are not always well integrated in the more central systems. The concepts in Isentris 3.0 open doors towards integrating these solutions into more homogeneous user interfaces. Combined with the more modern user interface and flexible environment this has led Novo Nordisk into starting the replacement of central ISIS applications.

Research Track | Product Demonstration | Birds of a Feather Breakout Discussions